Medicare GLP-1 cost comparison for 2026.
What you actually pay for a GLP-1 on Medicare depends on the drug, the indication your clinician documents, your Part D plan, and whether you qualify for the 2026 Bridge Program. This side-by-side breaks down the ranges honestly.
Educational only — your actual price depends on your specific plan, deductible, and pharmacy. Confirm with your Part D plan or ask us to look it up with you.
| Drug | Indication | Medicare covered? | Typical Part D cost/mo | Bridge Program |
|---|---|---|---|---|
| Wegovy (semaglutide) | Weight loss; cardiovascular risk reduction | Yes, when prescribed for CV risk reduction or via Bridge Program | $100–$500/mo depending on plan tier and deductible | $50/mo if eligible |
| Zepbound (tirzepatide) | Weight loss; obstructive sleep apnea | Limited; broader access via Bridge Program starting July 2026 | $100–$550/mo when covered | $50/mo if eligible |
| Ozempic (semaglutide) | Type 2 diabetes | Yes, for diabetes | $40–$300/mo depending on plan | Not part of Bridge Program |
| Mounjaro (tirzepatide) | Type 2 diabetes | Yes, for diabetes | $40–$400/mo depending on plan | Not part of Bridge Program |
| Rybelsus (oral semaglutide) | Type 2 diabetes | Yes, for diabetes | $50–$350/mo depending on tier | Not part of Bridge Program |
- Wegovy (semaglutide): The CV indication is what unlocks Part D coverage for many patients.
- Zepbound (tirzepatide): Sleep-apnea indication is expanding Medicare coverage in some plans.
- Ozempic (semaglutide): Widely covered when prescribed for diabetes; not covered for weight loss alone.
- Mounjaro (tirzepatide): Same active ingredient as Zepbound but priced/covered under diabetes rules.
- Rybelsus (oral semaglutide): Oral option for patients who prefer to avoid injections.
Three levers that actually move the price.
1. Match the indication to the drug
Medicare covers GLP-1s when the indication is one Medicare pays for — diabetes for Ozempic/Mounjaro, cardiovascular risk for Wegovy, sleep apnea for Zepbound. Getting the paperwork right is often worth $200+ per month.
2. Pick the right Part D plan during Open Enrollment
Formularies vary widely. The same drug can cost $60/month on one plan and $350 on another. Use Medicare.gov Plan Finder in October–December to compare — see our step-by-step guide.
3. Stack Bridge Program + Extra Help if eligible
The 2026 Bridge Program caps Wegovy and Zepbound at $50/mo for eligible Medicare patients. Low- and moderate-income patients may qualify for Extra Help, which reduces Part D costs further.
Not sure what you'd pay?
We'll look up your plan's formulary with you on a free 15-minute call and lay out the real out-of-pocket cost before you commit.
Book a ConsultationKeep reading.
Wegovy vs Zepbound for Medicare patients
Head-to-head comparison: results, side effects, cost, and Medicare coverage.
Read guideWegovy pill cost & Medicare coverage
How much the oral Wegovy pill costs under Medicare and the 2026 Bridge Program.
Read guideDoes Medicare cover Wegovy or Zepbound in 2026?
Coverage rules for GLP-1s under Medicare Part D, with the new pathways.
Read guide